Kidney cancer is a disease in which cancer cells grow in the kidneys. The kidneys are two bean-shaped organs. They are located just above the waist, on each side of the spine. Their main function is to filter the blood and produce urine.
There are 2 main types of kidney cancer:
|Cancer Cell Growth|
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Cancer occurs when cells in the body divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue forms, called a growth or tumor. The term cancer refers to malignant growths. These growths can invade nearby tissues. Cancer that has invaded nearby tissues can then spread to other parts of the body.
It is not clear exactly what causes these problems in the cells, but it is probably a combination of genetics and environment.
Kidney cancer is more common in men, and in people over 50 years old. Other factors that may increase your risk for kidney cancer include:
Kidney cancer may cause:
Your doctor will ask about your symptoms and medical history. A physical exam will be done.
Your bodily fluids and tissues may be tested. This can be done with:
Other tests evaluate the kidneys and other structures. These may include:
The physical exam combined with all of your test results, will help to determine the stage of cancer you have. Staging is used to guide your treatment plan. Like other cancers, kidney cancer is staged from I-IV. Stage I is a very localized cancer, while stage IV indicates a spread to other parts of the body.
Cancer treatment varies depending on the stage and type of cancer. Surgery is the most important component of any approach to cure kidney cancer. There is some information suggesting immunotherapies may be of some benefit. Radiation therapy can be used to treat kidney cancer that has spread to the lung, bones, or brain, but it is not a cure. Chemotherapy is not a very effective form of treatment.
Surgery involves the removal of a cancerous tumor, nearby tissue, and possibly nearby lymph nodes. Surgeries to treat kidney cancer include:
This is the use of radiation to kill cancer cells and shrink tumors. External radiation therapy is directed at the tumor from a source outside the body.
Chemotherapy is the use of drugs to kill cancer cells.
This procedure involves the use of drugs like interleukin-2 and interferon alpha to help the immune system fight and destroy cancer cells.
Targeted therapy includes using medications called tyrosine kinase inhibitors. These medications have been shown to increase the survival rate in people with kidney cancer. Another class of drugs called mammalian target of rapamycin (mTOR) inhibitors may also help people with kidney cancer live longer.
These medications may be prescribed to adults with advanced kidney cancer:
Measures to prevent kidney cancer are limited. In general: